PhD defence Sabine Denissen

Cardiovascular diseases are still common worldwide. Considering that there are risk assessment tools and preventive measures available, it has been suggested that population-based screening might be a promising strategy for identifying potential high-risk persons and consequently start preventive treatment. The ROBINSCA trial investigates whether screening for a high risk of cardiovascular diseases followed by preventive measures in asymptomatic individuals reduces cardiovascular morbidity and mortality. This thesis describes the secondary outcomes of the ROBINSCA screening trial, including contamination of screening arms, the impact of screening on participants, the risk distribution among the asymptomatic population and the potential reduction in overtreatment.